Endogenous Antioxidants and Three Paradoxes of Hypoxic Preconditioning
نویسندگان
چکیده
منابع مشابه
Epigenetic mechanisms of hypoxic preconditioning
MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...
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28. Giclas. P. C.. Pinckard. R. N. & Olson, M. S. ( I9791 J. lmmim~il. 122.146-151 Mullane, K. M.. Read. N.. Salmon. J . & Moncada. S. ( I 984) ./. I'liiirrnccc~ol. Exp. U w r . 228. 5 10-522 ('hamhers. I). E.. Parks. 1). A.. Patterson. G.. Roy. R.. McCord. J . M.. Oshida. S.. Parmley. L. F. & Ilowney. J . M. ( 1985) J. ,\lo/. C '?I/. C 'ctrcliol. 1 7. I 4 5 I 5 2 Wems. S. W.. Shea. M. J.. Mits...
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Background: Antioxidants such as α-tocopherol (vitamin E) and β-carotene (vitamin A) play an important role in protective effect of repeated brief periods of ischemia, namely ischemic preconditioning (IPC). Values of these antioxidants were investigated and compared after induction of ischemia reperfusion (IR) and kidney IPC in both male and female rats. Methods: Forty eight Wistar rats were di...
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Introduction: Ischemic Preconditioning (IPC) is the phenomen that happens on the heart by one or several short periods of ischemia followed by reperfusion that improve the postischemic recovery of mechanical function. Ischemic preconditioning (IPC) may protect the heart from ischemia reperfusion injury by nitric oxide formation. This study investigated the effect of ischemic preconditioni...
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To find a protein kinase C (PKC)-independent preconditioning mechanism, hypoxic preconditioning (HP; i.e., 10-min anoxia and 10-min reoxygenation) was applied to isolated rat hearts before 60-min global ischemia. HP led to improved recovery of developed pressure and reduced end-diastolic pressure in the left ventricle during reperfusion. Protection was unaffected by the PKC inhibitor bisindolyl...
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ژورنال
عنوان ژورنال: Wilderness & Environmental Medicine
سال: 2015
ISSN: 1080-6032
DOI: 10.1016/j.wem.2014.11.010